Wang, Jeff

Department Of Mechanical Engineering

Latrobe Hall 108
3400 N Charles St
(410) 516-7086

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Johns Hopkins scholars, leaders celebrate faculty research awards

September 4, 2015

Scholars from across Johns Hopkins University’s 10 divisions gathered last night at the George Peabody Library to celebrate 60 innovative research projects that are being supported by the inaugural Catalyst and Discovery awards. Thirty-seven early career scholars (five of them from WSE) received Catalyst Awards and 23 cross-divisional faculty teams, which included 14 WSE faculty […]

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Tiny Lab Devices Could Attack Huge Problem of Drug-Resistant Infections

April 24, 2015

A Johns Hopkins engineer, supported by a major NIH grant, is leading a multi-institution team that wants to keep bacterial infections from dodging the dwindling arsenal of drugs that destroy the deadly microbes. The group’s goal is to build palm-size devices that can quickly figure out which germ is causing a hospital-linked infection and then […]

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  • Ph.D. 2002, University of California, Los Angeles
  • M.S. 1994, National Taiwan University
  • B.S. 1992, National Taiwan University
Research Areas
  • BioMEMS and Microfluidics
  • Nano/Micro Scale Fabrication
  • Single Molecule Manipulation and Detection
  • Genetic and Epigenetic Biomarker for cancer
  • 2014:  JHU PURA awarded to Wang’s student Polly Ma
  • 2014:  Viterbi Postdoctoral Fellowship awarded to Wang’s student Tushar Rane
  • 2013:  Burroughs Wellcome Fund Career Award at the Scientific Interface awarded to Wang's postdoc Stephanie Fraley
  • 2013:  JALA & JBS Art of Science Award awarded to Wang's students Y Zhang and C Beh
  • 2013:  Siebel Scholar Award awarded to Wang's student Tushar Rane
  • 2012:  Best Paper Award - The 6th IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE NANOMED 2012)
  • 2012:  Burroughs Wellcome Fund Career Award at the Scientific Interface
  • 2012:  JALA & JBS Art of Science Award awarded to Wang's students Y Zhang and C Beh
  • 2012:  NIST/ Lab on a Chip Art in Science Award - micro-TAS 2012 - awarded to Wang's graduate student Yi Zhang
  • 2012:  Siebel Scholar Award awarded to Wang's student Yi Zhang
  • 2011:  Best Paper Award - The 6th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE NEMS 2011)
  • 2011:  Best Poster Award - 5th Annual INBT NanoBio Symposium
  • 2011:  Early Career Award from Thrasher Research Fund awarded to Wang's postdoc Seungkung Park
  • 2011:  JALA Ten Award - Journal of Laboratory Automation - Society for Laboratory Automation and Screening
  • 2011:  NIST/ Lab on a Chip Art in Science Award - micro-TAS 2011 - awarded to Wang's graduate student DJ Shin and Yi Zhang
  • 2010:  American Association for Cancer Research (AACR) Scholar-in-Training Award awarded to Wang's graduate student Yi Zhang
  • 2010:  Best Poster Award - 4th Johns Hopkins NanoBio Symposium
  • 2010:  Siebel Scholar Award awarded to Wang's graduate student Kelvin Liu
  • 2009:  Best Poster Award - 3rd Johns Hopkins NanoBio Symposium
  • 2009:  Johns Hoplins University WSE Dean’s Leadership Award
  • 2009:  Siebel Scholar Award awarded to Wang's graduate student Vas Bailey
  • 2007:  Co-author and Faculty Advisor to Hunter Chen - winner of Excellence in Research Award - American Society of Gene Therapy
  • 2007:  CRS Jorge Heller Award - Journal of Controlled Release Oustanding Paper Award
  • 2006:  CAREER Award - National Science Foundatiom
  • Seminar at the Institute of Systems Biology and Bioinformatics, National Central University, Jhongli, Taiwan.  Jhongli, Taiwan, .  November 14, 2014
  • DuPone Pioneer Hi-Bred Seminar Series.  Johnston, Iowa.  November 9, 2014
  • The Don P. Giddens Inaugural Professional Lecture Series, Johns Hopkins University.  Baltimore.  November 6, 2014
  • "HEAT-SHRUNKEN HIERARCHICAL SILICA NANOMEMBRANE FOR SOLID PHASE DNA EXTRACTION", 2014 Biomedical Engineering Society Meeting (BMES 2014).  San Antonio.  2014
  • International Conference on Optical MEMS and Nanophotonics (OMN 2014).  Glasgow, Scotland.  August 17, 2014
  • The 1st Mid-Atlantic DNA Nanotechnology Symposium.  Baltimore.  August 8, 2014
  • "Integrated droplet microfluidic platform for nucleic acids amplification test of Chlamydia trachomatis infection", The 24th Anniversary World Congress on Biosensors (Biosensors 2014).  Melbourne, Australia.  May 29, 2014
  • Nano@Wayne Seminar Series.  Detroit,.  April 25, 2014
  • Nano@Wayne Seminar Series, Wayne State University.  Detroit.  April 25, 2014
  • The 9th IEEE International Conference on Nano/Micro Engineering and Molecular Systems.  Hawaii.  April 13, 2014
  • "AUTOMATED DROPLET-ON-A-CHIP PLATFORM FOR CHLAMYDIA TRACHOMATIS DNA DETECTION ", Spring 2014 Symposium: From Lab to Life: Field Based Applications of MEMS and NEMS.  Baltimore.  2014
  • The 21st Annual Molecular Medicine Tri-Conference in Circular Cell-free DNA.  San Francisco.  February 14, 2014
  • ASME 3rd Global Congress on NanoEngineering for Medicine and Biology (NEMB2014).  San Francisco.  February 4, 2014
  • ASME 3rd Global Congress on NanoEngineering for Medicine and Biology (NEMB2014) .  San Francisco.  February 3, 2014
  • The 5th Annual Lab-On-A-Chip World Congress,.  San Diego.  September 13, 2013


Journal Articles
  • Rane, T. D., Zec, H. C., Wang, T. H. (2015).  A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening.  Anal Chem.
  • Shin, D. J., Zhang, Y., Wang, T. (2014).  A droplet microfluidic approach to single-stream nucleic acid isolation and mutation detection.  Microfluidics and Nanofluidics.  17(2).  425-430.
  • Beh, C. W., Pan, D., Lee, J., Jiang, X., Liu, K. J., Mao, H., Wang, T. (2014).  Direct Interrogation of DNA Content Distribution in Nanoparticles by a Novel Microfluidics-Based Single-Particle Analysis.  Nano Letters.  14(8).  4729-4735.
  • Athamanolap, P., Shin, D. J., Wang, T. (2014).  Droplet Array Platform for High-Resolution Melt Analysis of DNA Methylation Density.  Jala.  19(3).  304-312.
  • Song, Y., Liu, K. J., Wang, T. (2014).  Elimination of Ligation Dependent Artifacts in T4 RNA Ligase to Achieve High Efficiency and Low Bias MicroRNA Capture.  Plos One.  9(4).
  • Zhang, Y., Wang, T. H. (2014).  High-resolution quantification by charge-dominant electrophoretic mobility shift of quantum dots.  Electrophoresis.
  • Zhang, L., Song, Y., Fujita, T., Zhang, Y., Chen, M., Wang, T. (2014).  Large Enhancement of Quantum Dot Fluorescence by Highly Scalable Nanoporous Gold.  Advanced Materials.  26(8).  1289-1294.
  • Shin, D. J., Wang, T. (2014).  Magnetic Droplet Manipulation Platforms for Nucleic Acid Detection at the Point of Care.  Annals of Biomedical Engineering.  42(11).  2289-2302.
  • Rane, T. D., Chen, L., Zec, H. C., Wang, T. H. (2014).  Microfluidic continuous flow digital loop-mediated isothermal amplification (LAMP).  Lab Chip.
  • Zec, H., Shin, D. J., Wang, T. (2014).  Novel droplet platforms for the detection of disease biomarkers.  Expert Review of Molecular Diagnostics.  14(7).  787-801.
  • Nalayanda, D. D., Fulton, W. B., Colombani, P. M., Wang, T., Abdullah, F. (2014).  Pressure induced lung injury in a novel in vitro model of the alveolar interface: Protective effect of dexamethasone.  Journal of Pediatric Surgery.  49(1).  61-65.
  • Pisanic, II, T. R., Zhang, Y., Wang, T. H. (2014).  Quantum dots in diagnostics and detection: principles and paradigms.  Analyst.  139(12).  2968-2981.
  • Guzzetta, A. A., Pisanic, Ii, T. R., Sharma, P., Yi, J. M., Stark, A., Wang, T. H., Ahuja, N. (2014).  The promise of methylation on beads for cancer detection and treatment.  Expert Rev Mol Diagn.  14(7).  845-52.
  • Athamanolap, P., Parekh, V., Fraley, S. I., Agarwal, V., Shin, D. J., Jacobs, M., Wang, T., Yang, S. (2014).  Trainable High Resolution Melt Curve Machine Learning Classifier for Large-Scale Reliable Genotyping of Sequence Variants.  Plos One.  9(10).
  • Nalayanda, D. D., Fulton, W. B., Wang, T., Abdullah, F. (2013).  A multiphase fluidic platform for studying ventilator-induced injury of the pulmonary epithelial barrier.  Integrative Biology.  5(9).  1141-1148.
  • Zhang, Y., Park, S., Yang, S., Wang, T. (2013).  An all-in-one microfluidic device for parallel DNA extraction and gene analysis (vol 12, pg 1043, 2010).  Biomedical Microdevices.  15(2).  383.
  • Wang, T. H. (2013).  Discerning single molecule interactions of DNA and quantum dots.  Biotechnology Journal.  8(1).  15-16.
  • Keeley, B., Stark, A., Pisanic, II, T. R., Kwak, R., Zhang, Y., Wrangle, J., Baylin, S., Herman, J., Ahuja, N., Brock, M. V., Wang, T. (2013).  Extraction and processing of circulating DNA from large sample volumes using methylation on beads for the detection of rare epigenetic events.  Clinica Chimica Acta.  425.  169-175.
  • Zhang, Y., Wang, T. H. (2013).  Full-range magnetic manipulation of droplets via surface energy traps enables complex bioassays.  Adv Mater.  25(21).  2903-8.
  • Wang, T. (2013).  Micro and Nanotechnologies Enhanced Biomolecular Sensing.  Biosensors.  3(3).  283-285.
  • Yi, J. M., Guzzetta, A. A., Bailey, V. J., Downing, S. R., Van Neste, L., Chiappinelli, K. B., Keeley, B. P., Stark, A., Herrera, A., Wolfgang, C., Pappou, E. P., Iacobuzio-Donahue, C. A., Goggins, M. G., Herman, J. G., Wang, T., Baylin, S. B., Ahuja, N. (2013).  Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer.  Clinical Cancer Research.  19(23).  6544-6555.
  • Zhang, Y., Shin, D. J., Wang, T. (2013).  Serial dilution via surface energy trap-assisted magnetic droplet manipulation.  Lab on a Chip.  13(24).  4827-4831.
  • Song, Y., Zhang, Y., Wang, T. (2013).  Single Quantum Dot Analysis Enables Multiplexed Point Mutation Detection by Gap Ligase Chain Reaction.  Small.  9(7).  1096-1105.
  • Chiou, C., Shin, D. J., Zhang, Y., Wang, T. (2013).  Topography-assisted electromagnetic platform for blood-to-PCR in a droplet.  Biosensors & Bioelectronics.  50.  91-99.
  • Fraley, S. I., Hardick, J., Masek, B. J., Athamanolap, P., Rothman, R. E., Gaydos, C. A., Carroll, K. C., Wakefield, T., Wang, T., Yang, S. (2013).  Universal digital high-resolution melt: a novel approach to broad-based profiling of heterogeneous biological samples.  Nucleic Acids Research.  41(18).
  • Rane, T. D., Zec, H. C., Wang, T. H. (2012).  A serial sample loading system: interfacing multiwell plates with microfluidic devices.  J Lab Autom.  17(5).  370-7.
  • Rane, T. D., Zec, H. C., Puleo, C., Lee, A. P., Wang, T. H. (2012).  Droplet microfluidics for amplification-free genetic detection of single cells.  Lab on a Chip.  12(18).  3341-7.
  • Zhang, Y., Liu, K. J., Wang, T. L., Shih, I., Wang, T. H. (2012).  Mapping DNA Quantity into Electrophoretic Mobility through Quantum Dot Nanotethers for High-Resolution Genetic and Epigenetic Analysis..  ACS Nano.  6(1).  858-64.
  • Zhang, Y., Wang, T. H. (2012).  Micro magnetic gyromixer for speeding up reactions in droplets.  Microfluidics and Nanofluidics.  12(5).  787-794.
  • Zec, H., Rane, T. D., Wang, T. H. (2012).  Microfluidic platform for on-demand generation of spatially indexed combinatorial droplets.  Lab on a Chip.  12(17).  3055-3062.
  • Beh, C. W., Zhou, W. Z., Wang, T. H. (2012).  PDMS-glass bonding using grafted polymeric adhesive - alternative process flow for compatibility with patterned biological molecules.  Lab on a Chip.  12(20).  4120-4127.
  • Zhang, Y., Wang, T. H. (2012).  Quantum dot enabled molecular sensing and diagnostics.  Theranostics.  2(7).  631-54.
  • Song, Y., Zhang, Y., Wang, T. H. (2012).  Single Quantum Dot Analysis Enables Multiplexed Point Mutation Detection by Gap Ligase Chain Reaction.  Small.
  • Zhang, Y., Park, S., Liu, K., Tsuan, J., Yang, S., Wang, T. (2011).  A surface topography assisted droplet manipulation platform for biomarker detection and pathogen identification.  Lab on a Chip.  11(3).  398-406.
  • Park, S., Zhang, Y., Lin, S., Wang, T. H., Yang, S. (2011).  Advances in microfluidic PCR for point-of-care infectious disease diagnostics.  Biotechnology Advances.  29(6).  830-839.
  • Park, S., Zhang, Y., Wang, T. H., Yang, S. (2011).  Continuous dielectrophoretic bacterial separation and concentration from physiological media of high conductivity.  Lab on a Chip - Miniaturisation for Chemistry and Biology.  11(17).  2893-2900.
  • Zhang, Y., Wang, T. H. (2011).  Quantum dots-enabled high-resolution analysis of gene copy number variation: Electrophoretic migration and band broadening of QD-DNA nanocomplex.  IEEE Nanotechnology Magazine.  5(2).  23-27.
  • Liu, K. J., Rane, T. D., Zhang, Y., Wang, T. H. (2011).  Single-molecule analysis enables free solution hydrodynamic separation using yoctomole levels of DNA.  Journal of the American Chemical Society.  133(18).  6898-6901.
  • Zhang, Y., Park, S., Yang, S., Wang, T. (2010).  An all-in-one microfluidic device for parallel DNA extraction and gene analysis.  Biomedical Microdevices.  12(6).  1043-1049.
  • Zhang, Y., Park, S., Yang, S., Wang, T. H. (2010).  An all-in-one microfluidic device for parallel DNA extraction and gene analysis..  Biomed Microdevices.  12(6).  1043-9.
  • RANE, T., PULEO, C., LIU, K., ZHANG, Y., LEE, A., WANG, T. (2010).  Counting single molecules in sub-nanolitre droplets.  Lab on a Chip.  10(2).  161-164.
  • Liu, K. J., Brock, M. V., Shih, I. M., Wang, T. H. (2010).  Decoding circulating nucleic acids in human serum using microfluidic single molecule spectroscopy.  Journal of the American Chemical Society.  132(16).  5793-5798.
  • Bailey, V. J., Keeley, B. P., Razavi, C. R., Griffiths, E., Carraway, H. E., Wang, T. (2010).  DNA methylation detection using MS-qFRET, a quantum dot-based nanoassay.  Methods.  52(3).  237-241.
  • Bailey, V. J., Keeley, B. P., Razavi, C. R., Griffiths, E., Carraway, H. E., Wang, T. H. (2010).  DNA methylation detection using MS-qFRET, a quantum dot-based nanoassay..  Methods.  52(3).  237-41.
  • Jiang, X., Zheng, Y., Chen, H. H., Leong, K. W., Wang, T. H., Mao, H. (2010).  Dual-sensitive micellar nanoparticles regulate dna unpacking and enhance gene-delivery efficiency.  Advanced Materials.  22(23).  2556-2560.
  • Nalayanda, D. D., Wang, Q., Fulton, W. B., Wang, T. H., Abdullah, F. (2010).  Engineering an artificial alveolar-capillary membrane: a novel continuously perfused model within microchannels.  Journal of Pediatric Surgery.  45(1).  45-51.
  • Bailey, V. J., Keeley, B. P., Zhang, Y., Ho, Y. P., Easwaran, H., Brock, M. V., Pelosky, K. L., Carraway, H. E., Baylin, S. B., Herman, J. G., Wang, T. H. (2010).  Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection.  ChemBioChem.  11(1).  71-74.
  • Wang, T., Bailey, V., Zhang, Y., Liu, K. (2010).  Quantum Dots DNA Nanosensors - Ultrasensitive Platform for Detecting Genomic Cancer Markers.  BIOforum Europe.  1-2.  28-30.
  • Bailey, V. J., Zhang, Y., Keeley, B. P., Yin, C., Pelosky, K. L., Brock, M., Baylin, S. B., Herman, J. G., Wang, T. H. (2010).  Single-tube analysis of DNA methylation with silica superparamagnetic beads.  Clinical Chemistry.  56(6).  1022-1025.
  • Wang, T. H., Wong, P. K. (2010).  Transforming Microfluidics into Laboratory Automation.  JALA - Journal of the Association for Laboratory Automation.  15(3).  A15-A16.
  • Wang, T., Wong, P. K. (2010).  Transforming Microfluidics into Laboratory Automation.  Jala.  15(3).  A15-A16.
  • Schiminovich, D., Catinella, B., Kauffmann, G., Fabello, S., Wang, J., Hummels, C., Lemonias, J., Moran, S., Wu, R., Giovanelli, R., Haynes, M., Heckman, T., Basu-Zych, A., Blanton, M., Brinchmann, J., Budavari, T., Goncalves, T., Johnson, B., Kennicutt, R., Madore, B., Martin, C., Rich, M., Tacconi, L., Thilker, D., Wild, V., Wyder, T. (2010).  The GALEX Arecibo SDSS Survey - II. The star formation efficiency of massive galaxies.  Monthly Notices of the Royal Astronomical Society.  408.  919-934.
  • Catinella, B., Schiminovich, D., Kauffmann, G., Fabello, S., Wang, J., Hummels, C., Lemonias, J., Moran, S., Wu, R., Giovanelli, R., Haynes, M., Heckman, T., Basu-Zych, A., Blanton, M., Brinchmann, J., Budavari, T., Goncalves, T., Johnson, B., Kennicutt, R., Madore, B., Martin, C., Rich, M., Tacconi, L., Thilker, D., Wild, V., Wyder, T. (2010).  The GALEX Arecibo SDSS Survey - I. Gas fraction scaling relations of massive galaxies and first data release.  Monthly Notices of the Royal Astronomical Society.  403.  683-708.
  • NALAYANDA, D., PULEO, C., FULTON, W., SHARPE, L., WANG, T., ABDULLAH, F. (2009).  An open-access microfluidic model for lung-specific functional studies at an air-liquid interface.  Biomedical Microdevices.  11(5).  1081-1089.
  • Ho, Y. P., Chen, H. H., Leong, K. W., Wang, T. H. (2009).  Combining QD-FRET and microfluidics to monitor DNA nanocomplex self-assembly in real-time.  Journal of visualized experiments : JoVE.  (30).
  • Zhang, Y., Bailey, V., Puleo, C., Easwaran, H., Griffiths, E., Herman, J., Baylin, S., Wang, T. (2009).  DNA methylation analysis on a droplet-in-oil PCR array.  Lab on a Chip.  1059-1064.
  • Chen, H. H., Ho, Y. P., Jiang, X., Mao, H., Wang, T. H., Leong, K. W. (2009).  Erratum to "Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET" [Nano Today 4 (2009) 125-134] (DOI:10.1016/j.nantod.2009.02.008).  Nano Today.  4(3).  280.
  • PULEO, C., AMBROSE, W., TAKEZAWA, T., ELISSEEFF, J., WANG, T. (2009).  Integration and application of vitrified collagen in multilayered microfluidic devices for corneal microtissue culture.  Lab on a Chip.  9(22).  3221-3227.
  • Puleo, C. M., Wang, T. H. (2009).  Microfluidic means of achieving attomolar detection limits with molecular beacon probes.  Lab on a Chip - Miniaturisation for Chemistry and Biology.  9(8).  1065-1072.
  • Puleo, C. M., Wang, T. (2009).  Microfluidic means of achieving attomolar detection limits with molecular beacon probes.  Lab on a Chip.  9(8).  1065-1072.
  • BAILEY, V., EASWARAN, H., ZHANG, Y., GRIFFITHS, E., BELINSKY, S., HERMAN, J., BAYLIN, S., CARRAWAY, H., WANG, T. (2009).  MS-qFRET: A quantum dot-based method for analysis of DNA methylation.  Genome Research.  19(8).  1455-1461.
  • Hoffmann, J., Miragliotta, J., Wang, J., Tyagi, P., Maddanimath, T., Gracias, D., Papadakis, S. (2009).  Scanning surface-enhanced Raman spectroscopy (SERS) of chemical agent simulants on templated Au-Ag nanowire substrates.  Proceedings of SPIE.  7318.  73180D.
  • CHEN, H., HO, Y., JIANG, X., MAO, H., WANG, T., LEONG, K. (2009).  Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET.  Nano Today.  4(2).  125-134.
  • Ho, Y. P., Chen, H. H., Leong, K. W., Wang, T. H. (2009).  The convergence of quantum-dot-mediated fluorescence resonance energy transfer and microfluidics for monitoring DNA polyplex self-assembly in real time.  Nanotechnology.  20(9).
  • Puleo, C. M., Yeh, H. C., Liu, K. J., Wang, T. H. (2008).  Coupling confocal fluorescence detection and recirculating microfluidic control for single particle analysis in discrete nanoliter volumes.  Lab on a Chip.  8(5).  822-825.
  • Liu, K. J., Wang, T. H. (2008).  Cylindrical illumination confocal spectroscopy: Rectifying the limitations of confocal single molecule spectroscopy through one-dimensional beam shaping.  Biophysical Journal.  95(6).  2964-2975.
  • Liu, K. J., Zhang, Y., Wang, T. H. (2008).  Detect the dots.  IEEE Nanotechnology Magazine.  2(1).  14-18.
  • Lim, T. C., Bailey, V. J., Ho, Y. P., Wang, T. H. (2008).  Intercalating dye as an acceptor in quantum-dot-mediated FRET.  Nanotechnology.  19(7).
  • CHEN, H., HO, Y., JIANG, X., MAO, H., WANG, T., LEONG, K. (2008).  Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum Dot-FRET.  Molecular Therapy.  16(2).  324-332.
  • Sun, T. M., Du, J. Z., Yan, L. F., Mao, H., Wang, J. (2008).  Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery.  Biomaterials.  29(32).  4348-4355.
  • Yeh, H. C., Puleo, C. M., Ho, Y. P., Bailey, V. J., Teck, C. L., Liu, K., Wang, T. H. (2008).  Tunable blinking kinetics of Cy5 for precise DNA quantification and single-nucleotide difference detection.  Biophysical Journal.  95(2).  729-737.
  • Puleo, C. M., Yeh, H. C., Wang, T. H. (2007).  Applications of MEMS technologies in tissue engineering.  Tissue Engineering.  13(12).  2839-2854.
  • Nalayanda, D. D., Puleo, C. M., Fulton, W. B., Wang, T. H., Abdullah, F. (2007).  Characterization of pulmonary cell growth parameters in a continuous perfusion microfluidic environment.  Experimental Lung Research.  33(6).  321-335.
  • Nathani, H., Wang, J., Weihs, T. (2007).  Long-term stability of nanostructured systems with negative heats of mixing.  Journal of Applied Physics.  101(10).
  • Chao, S. Y., Ho, Y. P., Bailey, V. J., Wang, T. H. (2007).  Quantification of low concentrations of DNA using single molecule detection and velocity measurement in a microchannel.  Journal of Fluorescence.  17(6).  767-774.
  • Yeh, H. C., Puleo, C. M., Lim, T. C., Ho, Y. P., Giza, P. E., Huang, R., Wang, T. H. (2006).  A microfluidic-FCS platform for investigation on the dissociation of Sp1-DNA complex by doxorubicin.  Nucleic Acids Research.  34(21).
  • HO, Y., CHEN, H., LEONG, K., WANG, T. (2006).  Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots-FRET.  Journal of Controlled Release.  116(1).  83-89.
  • YEH, H., HO, Y., SHIH, I., WANG, T. (2006).  Homogeneous point mutation detection by quantum dot-mediated two-color fluorescence coincidence analysis.  Nucleic Acids Research.  34(5).
  • Puleo, C. M., Liu, K., Wang, T. (2006).  Pushing miRNA quantification to the limits: high-throughput miRNA gene expression analysis using single-molecule detection.  Nanomedicine.  1(1).  123-127.
  • ZHANG, C., CHAO, S., WANG, T. (2005).  Comparative quantification of nucleic acids using single-molecule detection and molecular beacons.  Analyst.  130(4).  483-488.
  • Wang, J., Besnoin, E., Knio, O. M., Weihs, T. (2005).  Effects of physical properties of components on reactive nanolayer joining.  Journal of Applied Physics.  97(11).
  • Eagleton, T. S., Mallet, J., Cheng, X., Wang, J., Chien, C., Searson, P. (2005).  Electrodeposition of CoxPt1-x thin films.  Journal of the Electrochemical Society.  152(1).  C27-C31.
  • Trenkle, J. C., Wang, J., Weihs, T., Hufnagel, T. (2005).  Microstructural study of an oscillatory formation reaction in nanostructured reactive multilayer foils.  Applied Physics Letters.  87(15).
  • HO, Y., KUNG, M., YANG, S., WANG, T. (2005).  Multiplexed hybridization detection with multicolor colocalization of quantum dot nanoprobes.  Nano Letters.  5(9).  1693-1697.
  • Yeh, H. C., Ho, Y. P., Wang, T. H. (2005).  Quantum dot-mediated biosensing assays for specific nucleic acid detection..  Nanomedicine.  1(2).  115-21.
  • Yeh, H. C., Ho, Y. P., Wang, T. H. (2005).  Quantum dot-mediated biosensing assays for specific nucleic acid detection..  Nanomedicine.  1(2).  115-21.
  • YEH, H., CHAO, S., HO, Y., WANG, T. (2005).  Single-molecule detection and probe strategies for rapid and ultrasensitive genomic detection.  Current Pharmaceutical Biotechnology.  6(6).  453-461.
  • WANG, T., PENG, Y., ZHANG, C., WONG, P., HO, C. (2005).  Single-molecule tracing on a fluidic microchip for quantitative detection of low-abundance nucleic acids.  Journal of the American Chemical Society.  127(15).  5354-5359.
  • ZHANG, C., YEH, H., KUROKI, M., WANG, T. (2005).  Single-quantum-dot-based DNA nanosensor.  Nature Materials.  4(11).  826-831.
  • Zhang, P. C., Wang, J., Leong, K. W., Mao, H. (2005).  Ternary complexes comprising polyphosphoramidate gene carriers with different types of charge groups improve transfection efficiency.  Biomacromolecules.  6(1).  54-60.
  • Li, Y., Wang, J., Lee, C. G., Wang, C. Y., Gao, S. J., Tang, G. P., Ma, Y. X., Yu, H., Mao, H., Leong, K. W., Wang, S. (2004).  CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: A comparison with polyethylenimine/DNA complexes.  Gene Therapy.  11(1).  109-114.
  • WONG, P., CHEN, C., WANG, T., HO, C. (2004).  Electrokinetic bioprocessor for concentrating cells and molecules.  Analytical Chemistry.  76(23).  6908-6914.
  • WONG, P., WANG, T., DEVAL, J., HO, C. (2004).  Electrokinetics in micro devices for biotechnology applications.  IEEE-ASME Transactions on Mechatronics.  9(2).  366-376.
  • Wang, J., Lee, I. L., Lim, W. S., Chia, S. M., Yu, H., Leong, K. W., Mao, H. (2004).  Evaluation of collagen and methylated collagen as gene carriers.  International Journal of Pharmaceutics.  279(1-2).  115-126.
  • Wang, J., Besnoin, E., Knio, O. M., Weihs, T. (2004).  Investigating the effect of applied pressure on reactive multilayer foil joining.  Acta Materialia.  52(18).  5265-5274.
  • Wang, J., Besnoin, E., Duckham, A., Spey, S. J., Reiss, M. E., Knio, O. M., Weihs, T. (2004).  Joining of stainless-steel specimens with nanostructured Al/Ni foils.  Journal of Applied Physics.  95(1).  248-256.
  • Wan, A. C., Mao, H., Wang, S., Phua, S. H., Lee, G. P., Pan, J., Lu, S., Wang, J., Leong, K. W. (2004).  Poly(phosphoester) ionomers as tissue-engineering scaffolds.  Journal of Biomedical Materials Research - Part B Applied Biomaterials.  70(1).  91-102.
  • Wang, J., Gao, S. J., Zhang, P. C., Wang, S., Mao, H., Leong, K. W. (2004).  Polyphosphoramidate gene carriers: Effect of charge group on gene transfer efficiency.  Gene Therapy.  11(12).  1001-1010.
  • Duckham, A., Spey, S. J., Wang, J., Reiss, M. E., Weihs, T., Besnoin, E., Knio, O. M. (2004).  Reactive nanostructured foil used as a heat source for joining titanium.  Journal of Applied Physics.  96(4).  2336-2342.
  • Huang, S. W., Wang, J., Zhang, P. C., Mao, H., Zhuo, R. X., Leong, K. W. (2004).  Water-soluble and nonionic polyphosphoester: Synthesis, degradation, biocompatibility and enhancement of gene expression in mouse muscle.  Biomacromolecules.  5(2).  306-311.
  • Fang, N., Wang, J., Mao, H., Leong, K. W., Chan, V. (2003).  BHEM-Chol/DOPE liposome induced perturbation of phospholipid bilayer.  Colloids and Surfaces B: Biointerfaces.  29(4).  233-245.
  • Wang, J., Huang, S. W., Zhang, P. C., Mao, H., Leong, K. W. (2003).  Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoesters.  International Journal of Pharmaceutics.  265(1-2).  75-84.
  • Lu, H. F., Lim, W. S., Wang, J., Tang, Z. Q., Zhang, P. C., Leong, K. W., Chia, S. M., Yu, H., Mao, H. (2003).  Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance.  Biomaterials.  24(27).  4893-4903.
  • Zhao, Z., Wang, J., Mao, H., Leong, K. W. (2003).  Polyphosphoesters in drug and gene delivery.  Advanced Drug Delivery Reviews.  55(4).  483-499.
  • Wang, J., Besnoin, E., Duckham, A., Spey, S. J., Reiss, M. E., Knio, O. M., Powers, M., Whitener, M., Weihs, T. (2003).  Room-temperature soldering with nanostructured foils.  Applied Physics Letters.  83(19).  3987-3989.
  • Wang, J., Zhang, P. C., Mao, H., Leong, K. W. (2002).  Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier.  Gene Therapy.  9(18).  1254-1261.
  • Wang, J., Zhang, P. C., Lu, H. F., Ma, N., Wang, S., Mao, H., Leong, K. W. (2002).  New polyphosphoramidate with a spermidine side chain as a gene carrier.  Journal of Controlled Release.  83(1).  157-168.
  • Wang, J., Mao, H., Leong, K. W. (2001).  A novel biodegradable gene carrier based on polyphosphoester [19].  Journal of the American Chemical Society.  123(38).  9480-9481.
Book Chapters
  • Wang, T., Liu, K., Yeh, H., Puleo, C. (2010).  Nanobiosensors.  Microtechnology and Nanotechnology in Biomedical Applications.  Oxford University Press.  346-394.
Other Publications
  • Shin, D. J., Athamanolap, P., Chen, L., Wang, T. (2014).  Integrated droplet microfluidic platform for nucleic acids amplification test of Chlamydia trachomatis infection.
  • Zec, H., Glove, C., Hsieh, W., Liu, L., Keefe, C., Wang, T. (2014).  Methods for Controlling Water Evaporation in PDMS-Based Microfluidic Devices.
  • Rane, T., Zec, H., Wang, T. (2013).  A Multiplexed Microfluidic Droplet Platform for Matrix Metalloproteinase Screening.  1595-1597.
  • Wu, J., Friedrich, F., Liu, K., Wang, T. (2013).  Chip-Based DNA Separation in Free Solution by Inertial Hydrodynamic Forces.  578-580.
  • Zhang, Y., Zhang, Y., Wang, T. (2013).  Hierarchical Silica Nanomembrane Driven by Thermal Shrinkage and its Application for Solid Phase DNA Extraction.  IEEE.
  • Athamanolap, P., Keeley, B., Shin, D. J., Wang, T. (2013).  Quantitative Analysis of DNA Methylation Based on Melting Curve Analysis.  IEEE.  1116-1118.
  • Zhang, Y., Zhang, Y., Keely, B., Stark, A., Wang, T. (2013).  Spontaneous Shrinking Silica Nanomembrane for Solid Phase.  IEEE.
Conference Proceedings
  • Zec, H. C., Rane, T. D., Chu, W., Wang, V. W., Wang, T.  A microfluidic droplet platform for multiplexed single nucleotide polymorphism analysis of an array plant genomic DNA samples.  Micro Electro Mechanical Systems (MEMS), 2013 IEEE 26th International Conference on.  IEEE.  263-266.
  • Zhang, Y., Shih, I., Wang, T., Wang, T.  A Quantum Dot Based Nanoassay for Quantifying Gene Copy Number with Ultrahigh Resolution.  Proceesings: The 14th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2010).  1154-1156.
  • Wang, T. H., Masset, S., Ho, C. M.  A zepto mole DNA micro sensor.  Proceedings: 14th  IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS).  431-434.
  • Zhang, Y., Wang, T.  All-in-one droplet platform for multiplexed genetic detection in blood.  Micro Electro Mechanical Systems (MEMS), 2013 IEEE 26th International Conference on.  IEEE.  1061-1064.
  • Zhang, Y., Wang, T. H.  An active gyroscopic magnetic micromixer for rapid fluid mixing in droplet based microfluidic systems.  1769-1772.
  • Zhang, Y., Wang, T. H.  An automated all-in-one microfludic device for parallel solid phase dna extraction and droplet-inoil PCR analysis.  Proceesings: The 23rd IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS).  971-974.
  • Liu, K., Rane, T., Zhang, Y., Beh, C. W., Shin, D., Wang, T.  An Integrated Platform for Single Molecule Free Solution Hydrodynamic Separation Using Yoctomoles of DNA and Picoliter Samples.  ASME 10th International Conference on Nanochannels, Microchannels and Minichannels (ICNMM 2012).  ICNMM2012-73154 (p.1-6).
  • Puleo, C. M., Yeh, H. C., Liu, K. J., Rane, T., Wang, T. H.  Coupling evaporation-based, microfluidic concentration and confocal fluorescence spectroscopy.  Proceesings: 21st IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS).  200-203.
  • Zhang, Y., Shin, D., Wang, T.  Detecting Genetic Variations in a Droplet.  15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2011).  Royal Society of Chemistry.  1179-1181.
  • Shin, D., Stark, A., Wang, T.  Droplet bisulfite conversion platform for epigenetic cancer biomarker detection.  17th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2013).  IEEE.  2181-2184.
  • Zhang, Y., Wang, T.  Droplet Immobilization, Splitting, Metering and Aliquoting with Surface Energy Traps Created Using SU8 Shadow Mask.  16th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2012).  73-75.
  • Wang, T. H., Wong, P. K., Ho, C. M.  Electrical molecular focusing for laser induced fluorescence based single DNA detection.  Proceesings:15th  IEEE International Conference on Micro Electro Mechanical Systems(IEEE MEMS).  15-18.
  • Chiou, C., Shin, D., Hosmane, S., Zhang, Y., Wang, T.  Electromagnet-actuated droplet platform for sample-to-answer genetic detection.  Micro Electro Mechanical Systems (MEMS), 2013 IEEE 26th International Conference on.  IEEE.  98-101.
  • Zhang, Y., Zhang, Y., Keely, B., Stark, A., Wang, T.  Fabricating and Applying Hierarchical Silica Nanomembrane with for Solid Phase DNA Extraction.  The 6th IEEE International Conference on Nano/Molecular Medicine and Engineering (IEEE NANOMED 2012).
  • Zhang, Y., Wang, T.  Flip-drop: Droplet array created by surface energy trap for combinatorial screening.  Micro Electro Mechanical Systems (MEMS), 2013 IEEE 26th International Conference on.  1149-1152.
  • Zhang, Y., Park, S., Yang, S., Wang, T. H.  Fully integraed droplet based point-of-care platform for molecular detection from crude biosamples.  1927-1930.
  • Zhang, Y., Wang, T. H.  Geomorphology-assisted manipulation of magnet-actuated droplet for solid phase DNA extraction and droplet-in-oil PCR.  Proceedings: The 23rd IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS).  1047-1050.
  • Zhang, Y., Bailey, V., Puleo, C. M., Easwaran, H., Griffiths, E., Herman, J. G., Baylin, S. B., Wang, T. H.  High throughput DNA methylation analysis on a droplet-in-oil polymerase chain reaction array.  Proceesings: The 15th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2009).  806-808.
  • Murray, K., Wang, T. H., Rebello, K., Crookston, J., Miragliotta, J.  High-degree concentration of bio-agents using electrokinetic manipulations.  Proceedings: IEEE/NLM Life Science Systems and Application Workshop.  94-95.
  • Beh, C., Weiss, C., Mao, H., D.L., K., Wang, T.  High-Throughput Microfluidic Preparation of Imaging-Visible Embolic Beads.  EMBS Micro and Nanotechnology in Medicine Conference.  59.
  • Beh, C., Kraitchman, D., Mao, H., Wang, T.  High-throughput Monodisperse Alginate Gel Bead Formation using Microfluidic Pseudo-Check Valve.  Proceedings: The 14th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2010).
  • Rane, T., Zec, H., Puleo, C., Lee, A., Wang, T.  High-Throughput Single-Cell Pathogen Detection on a Droplet Microfluidic Platform.  Proceesings: 23rd IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS 2011).  881-884.
  • Zhuo, R. X., Wang, J., Mao, H., Xu, M. Y.  Immunological properties of polyphosphate-phosphoramide.  Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium.  2.  819.
  • Stark, A., Zhang, Y., Bailey, V., Keeley, B., Wang, T. H.  Increasing throughput and sensitivity of DNA Methylation analysis through functional nanoparticles.  1048-1051.
  • Ho, Y. P., Wang, T. H.  Multiplexed detection of anthrax sequences with quantum dot nanoprobes.  Proceedings: IEEE/NLM Life Science Systems and Application Workshop.  62-63.
  • Zec, H., Rane, T., Chu, W., Wang, T.  Multiplexed Screening of a Large Library of Biological Samples through on-Demand Droplet Generation and Fusion.  ASME 2012 10th International Conference on Nanochannels, Microchannels and Minichannels (ICNMM 2012).  ICNMM2012-73159 (p.1-6).
  • Wang, T. H., Ho, C. M.  Nano/micro technologies for single molecule manipulation and detection.  Proceedings: IEEE International Conference on Robotics and Control (IEEE ICRA).  3.  3630-3635.
  • Beh, C., Zhou, W., Wang, T.  Oxygen Plasma-Free Microfluidic Device Sealing.  Proceesings: The 14th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2010).  1217-1219.
  • Zec, H. C., Rane, T. D., Ma, P., Wang, T.  Parallelization offissionand fusion+ operations for high throughput generation of combinatorial droplets.  Micro Electro Mechanical Systems (MEMS), 2014 IEEE 27th International Conference on.  IEEE.  334-337.
  • Liu, K. J., Wang, T. H.  PCR-free, microfluidic single molecule analysis of circulating nucleic acids in lung cancer patient serum.  8392-8395.
  • Liu, K. J., Wang, T. H.  Quantitative confocal spectroscopy - rectifying the limitations of single molecule detection.  Proceedings: The 3rd Annual IEEE International Conferences on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS).  1189-1192.
  • Ho, Y. P., Chen, H. H., Puleo, C. M., Yeh, H. C., Leong, K. W., Wang, T. H.  Quantitative kinetic analysis of DNA nanocomplex self-assembly with quantum dots fret in a microfluidic device.  Proceedings: 21st IEEE International Conference on Micro Electro Mechanical Systems (IEEE MEMS).  30-33.
  • Zhang, Y., Wang, T.  Quantum dot electrophoretic mobility shift assay and its application to the measurement of exonuclease activity.  Nanotechnology (IEEE-NANO), 2012 12th IEEE Conference on.  IEEE.  1-4.
  • Keeley, B., Zhang, Y., Zhang, Y., Stark, A., Wang, T.  Quantum dot FRET linker probes for highly sensitive DNA methylation detection.  Nanotechnology (IEEE-NANO), 2012 12th IEEE Conference on.  IEEE.  1-4.
  • Yeh, H. C., Ho, Y. P., Wang, T. H.  Quantum dot-mediated separation-free assay for point mutation detection.  Proceesings: NSTI- Bio-Nanotechnology Conference.  198-201.
  • Wang, T. H., Bailey, V., Liu, K.  Quantum dots and microfluidic single-molecule detection for screening genetic and epigenetic cancer markers in clinical samples.  8031.
  • Bailey, V. J., Puleo, C. M., Ho, Y. P., Yeh, H. C., Wang, T. H.  Quantum dots in molecular detection of disease.  Conference proceedings:Annual International Conference of the IEEE Engineering in Medicine and Biology Society..  2009.  4089-4092.
  • Zhang, Y., Wang, T. H.  Quantum dots-enabled high resolution analysis of gene copy number variation.  800-803.
  • Yeh, H. C., Simone, E., Zhang, C., Wang, T. H.  Single bio-molecule detection with quantum dots in a microchannel.  Proceedings: 17h IEEE  Annual Workshop of Micro Electro Mechanical Systems (IEEE MEMS).  371-374.
  • Song, Y., Zhang, L., Chen, M., Wang, T.  Single quantum dot fluorescence enhancement by tunable nanoporous gold.  Nanotechnology (IEEE-NANO), 2012 12th IEEE Conference on.  IEEE.  1-5.
  • Song, Y., Zhang, Y., Wang, T.  Single Quantum Dot-Based Multiplexed Point Mutation Detection by Gap Ligase Chain Reaction.  15th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2011).  Royal Society of Chemistry.  1779-1781.
  • Zhang, Y., Wang, T.  Surface Energy Trap Assisted Rapid Serial Dilution on Droplet Platform for Bacteria Antibiotics Susceptibility Test.  16th International Conference on Miniaturized Chemical and Biochemical Analysis Systems (micro-TAS 2012).  467-469.
  • Yeh, H. C., Puleo, C. M., Ho, Y. P., Wang, T. H.  Towards single-molecule diagnostics using microfluidic manipulation and quantum dot nanosensors.  Proceedings: 5th International Conference on Nanochannels, Microchannels and Minichannels, (ICNMM2007).  1133-1140.
  • Hoffmann, J., Miragliotta, J., Wang, J., Tyagi, P., Maddanimath, T., Gracias, D., Papadakis, S. (2012).  Nanowire-based surface-enhanced Raman spectroscopy (SERS) for chemical warfare simulants.  SPIE Defense, Security, and Sensing.  837323–837323.
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