Course Descriptions

EN.540.101. Chemical Engineering Today. 1 Credit.

A series of weekly lectures to introduce students to chemical and biomolecular engineering and its role as a profession in addressing contemporary technological, social, ethical, and economic issues in today’s world. The lectures will include examples of how chemical and biomolecular engineers apply the principles of physics and chemistry to develop new products, improve process efficiencies, and alleviate the strain on the ecosystem through the design of novel environmentally conscious processes. In addition, the lectures will highlight exciting new areas now being advanced by chemical and biomolecular engineers, such as biochemical engineering, tissue engineering, nanoparticle fabrication, and processing smart polymers for applications in computer technology and as sensors. Freshmen Only.
Instructor(s): L. Dahuron
Area: Engineering.

 

EN.540.202. Introduction to Chemical & Biological Process Analysis. 4 Credits.

Introduction to chemical and biomolecular engineering and the fundamental principles of chemical process analysis. Formulation and solution of material and energy balances on chemical processes. Reductionist approaches to the solution of complex, multi-unit processes will be emphasized. Introduction to the basic concepts of thermodynamics as well as chemical and biochemical reactions.
Prerequisites: Co-requisite: AS.030.205
Instructor(s): L. Dahuron
Area: Engineering.

 

EN.540.203. Engineering Thermodynamics. 3 Credits.

Formulation and solution of material, energy, and entropy balances with an emphasis on open systems. A systematic problem-solving approach is developed for chemical and biomolecular process-related systems. Extensive use is made of classical thermodynamic relationships and constitutive equations for one and two component systems. Applications include the analysis and design of engines, refrigerators, heat pumps, compressors, and turbines.
Prerequisites: EN.540.202
Instructor(s): M. Bevan
Area: Engineering.

 

EN.540.204. Applied Physical Chemistry. 3 Credits.

The topics in this course include thermodynamic models for multicomponent phase equilibrium including vapor liquid equilibrium, phase diagrams, activity models and colligative properties in both non-electrolyte and electrolyte solutions. . A link between average thermodynamic properties and microstates and molecular interactions is made via a discussion of intermolecular forces and the partition function. Also covered are thermodynamic relationships to describe chemical equilibria, and basic concepts in quantum mechanics and statistical mechanics.
Prerequisites: EN.540.203.
Instructor(s): D. Gracias
Area: Engineering.

 

EN.540.301. Kinetic Processes. 4 Credits.

Review of numerical methods applied to kinetic phenomena and reactor design in chemical and biological processes. Homogeneous kinetics and interpretation of reaction rate data. Batch, plug flow, and stirred tank reactor analyses, including reactors in parallel and in series. Selectivity and optimization considerations in multiple reaction systems. Non isothermal reactors. Elements of heterogeneous kinetics, including adsorption isotherms and heterogeneous catalysis. Coupled transport and chemical/biological reaction rates.
Prerequisites: EN.540.203 AND EN.540.303
Instructor(s): A. Goffin; H. Cui
Area: Engineering.

 

EN.540.303. Transport Phenomena I. 3 Credits.

Molecular mechanisms of momentum transport (viscous flow), energy transport (heat conduction), and mass transport (diffusion). Isothermal equations of change (continuity, motion, and energy). The development of the Navier Stokes equation. The development of non isothermal and multi component equations of change for heat and mass transfer. Exact solutions to steady state, isothermal unidirectional flow problems, to steady state heat and mass transfer problems. The analogies between heat, mass, and momentum transfer are emphasized throughout the course. Recommended Corequisite: AS.110.302, Introduction to the field of transport phenomena.
Instructor(s): J. Frechette
Area: Engineering, Natural Sciences.

 

EN.540.304. Transport Phenomena II. 4 Credits.

Dimensional analysis and dimensionless groups. Laminar boundary layers, introduction to turbulent flow. Definition of the friction factor. Macroscopic mass, momentum and mechanical energy balances (Bernouilli’s equation). Metering of fluids. Convective heat and mass transfer. Heat and mass transfer in boundary layers. Correlations for convective heat and mass transfer. Boiling and condensation. Interphase mass transfer.
Prerequisites: EN.540.303.
Instructor(s): Z. Gagnon
Area: Engineering, Natural Sciences.

 

EN.540.305. Modeling and Statistical Analysis of Data for Chemical and Biomolecular Engineers. 3 Credits.

This course seeks to build the student’s strength in Chemical Engineering computing and data analysis. To this end, in the first part of the course, we will become familiar with the Matlab/Octave computing environment and solve problems in Chemical Engineering that involve concepts from Process Analysis, Thermodynamics, Transport Phenomena, and Kinetics. In the subsequent part, we will build on the skills learnt earlier and tackle problems in Data Analysis and Hypothesis testing. Recommended Corequisites: EN.540.203 and EN.540.304.
Prerequisites: Corequisite: EN.540.303
Instructor(s): R. Schulman
Area: Engineering.

 

EN.540.306. Chemical & Biomolecular Separation. 3 Credits.

This course covers staged and continuous-contacting separations processes critical to the chemical and biochemical industries. Separations technologies studied include distillation, liquid-liquid extraction, gas absorption, membrane ultrafiltration, reverse osmosis, dialysis, adsorption, and chromatography. Particular emphasis is placed on the biochemical uses of these processes and consequently on how the treatment of these processes differs from the more traditional approach.
Prerequisites: EN.540.303 AND EN.540.202
Instructor(s): M. Betenbaugh
Area: Engineering.

EN.540.309. Chemical and Biomolecular Engineering Design Part 1. 3 Credits.

This course guides the student through the contrasting aspects of product design and of process design. Product design concerns the recognition of customer needs, the creation of suitable specifications, and the selection of best products to fulfill the needs. Process design concerns the quantitative description of processes which serve to produce many commodity chemicals, the estimation of process profitability, and the potential for profitability improvement through incremental changes in the process. Students work in small teams to complete a major project demonstrating their understanding of and proficiency in the primary objectives of the course. Students report several times both orally and in writing on their accomplishments. This course is the first part two semester sequence that optionally can be taken instead of for EN.540.314 Chemical and Biomolecular Engineering Product and Process Design. The material covered is the same as in EN.540.314, but more time is allowed so that laboratory tests can be performed and/or prototypes can be made. Note that both courses in this sequence must be taken in order to satisfy the requirement that students take EN.540.314 as part of the Chemical and Biomolecular Engineerng program. Recommended Course Background: EN.540.301, EN.540.304, EN.540.311 or EN.540.313 or permission of instructor.
Instructor(s): M. Donohue
Area: Engineering, Natural Sciences.

 

EN.540.311. Chemical Engineering Lab I. 6 Credits.

Students will have additional meeting times outside of class. Students are challenged with laboratory projects that are not well-defined and learn to develop an effective framework for approaching experimental work by identifying the important operating variables, deciding how best to obtain them, and using measured or calculated values of these operating variables to predict, carryout, analyze and improve upon experiments. Each student analyzes three of the following four projects: distillation, gas absorption, liquid-liquid extraction and chemical kinetics in a tubular flow reactor and also one of the projects in EN.540.313. In addition to technical objectives, this course stresses oral and written communication skills and the ability to work effectively in groups.
Prerequisites: EN.540.301, EN.540.304, EN.540.306, EN.540.490 and EN.661.315
Instructor(s): A. Goffin; L. Dahuron
Area: Engineering
Writing Intensive.

 

EN.540.312. Chemical and Biomolecular Engineering Lab: Part 2. 3 Credits.

Students who, as a part of an exchange program, participated in a laboratory course at the Technical University of Denmark at Copenhagen during the summer of 2010 are required to register for this course to complete their equivalency requirement for the Chemical and Biomolecular Engineering Laboratory course offered in Fall 2010 at JHU. This course comprises of four parts: (i) a research-oriented study of one of the seven experiments done at Copenhagen to be submitted as a report, (ii) performance of one experimental project and submission of report along with the current Senior Lab students, (iii) a 15-min presentation of experimental work done at Copenhagen, and (iv) a 5-min presentation to the current junior class describing the overall experience. Recommended Course Background: EN.540.301, EN.540.304, EN.540.306, EN.540.490, EN.661.315
Instructor(s): L. Dahuron
Area: Engineering
Writing Intensive.

 

EN.540.313. Chemical and Biomolecular Engineering Lab. 6 Credits.

Students are challenged with laboratory projects that are not well-defined and learn to develop an effective framework for approaching experimental work by identifying the important operating variables, deciding how best to obtain them, and using measured or calculated values of these operating variables to predict, carryout, analyze and improve upon experiments. Each student analyzes three biomolecular engineering projects and one of the projects in EN.540.311. In addition to technical objectives, this course stresses oral and written communication skills and the ability to work effectively in groups. Students will have additional meeting times outside of class. Recommended Course Background: EN.540.301, EN.540.304, EN.540.306, EN.540.490, EN.661.315
Instructor(s): A. Goffin; L. Dahuron; M. Ostermeier; S. Gerecht
Area: Engineering
Writing Intensive.

 

EN.540.314. Chemical Engineering Poduct & Process Design. 4 Credits.

This course guides the student through the contrasting aspects of product design and of process design. Product design concerns the recognition of customer needs, the creation of suitable specifications, and the selection of best products to fulfill the needs. Process design concerns the quantitative description of processes, which serve to produce many commodity chemicals, the estimation of process profitability, and the potential for profitability improvement through incremental changes in the process. Students work in small teams to complete a major project demonstrating their understanding of and proficiency in the primary objectives of the course. Students report several times both orally and in writing on their accomplishments.
Prerequisites: ( EN.540.311 OR EN.540.313 ) AND EN.540.301AND EN.540.306
Instructor(s): A. Goffin; L. Dahuron; M. Donohue
Area: Engineering.

 

EN.540.400. Project in Design: Pharmacokinetics. 3 Credits.

This design project will be to develop a chemical process model of the human body that can be used to understand the temporal distribution, spatial distribution and bioavailability of pharmaceutical drugs. The course (and software to be developed) will cover the spectrum of factors affecting pharmaceutical bioavailability including drug formulation, mode of dosing and dosing rate, metabolism and metabolic cascades, storage in fatty tissues, and diffusional limitations (such as in crossing the blood-brain barrier or diffusional differences between normal and cancerous cells). The goal is to develop a process model of the human body that will predict pharmaceutical bioavailability as a function of time and organ (or cell) type that will work for a wide variety of pharmaceuticals including small molecules, biologics, and chemotherapy agents.
Instructor(s): M. Donohue
Area: Engineering.

 

EN.540.401. Projects in Design: Alternative Energy. 3 Credits.

This course is a group design project (i.e. not a lecture course) to use chemical processing simulation tools (Aspen) to model a real-world process of interest to Chemical and Biomolecular Engineers. The goal of the project will be to develop a process model that is sufficiently complete and robust that it can be used to understand the important factors in the process design and/or operation. This design project is focused on the role alternative energy will play in our country’s future. About a third of the course will be devoted to understanding the role of energy and alternative energy in the US and world economies. The remainder of the course will be devoted to a technical and economic analysis of the feasibility of making biofuel from algae.
Instructor(s): M. Donohue
Area: Engineering.

 

EN.540.402. Metabolic Systems Biotechnology. 3 Credits.

The aim of this course is to provide a fundamental understanding of the quantitative principles and methodologies of systems biology and biochemical engineering of metabolism. This includes concepts of cellular growth, cellular stoichiometric models, metabolic networks, metabolite fluxes, and genome-scale metabolic models. Quantitative methods and systems biology approaches for metabolic flux analysis and metabolic control theory will be included as well as an analysis of biochemical systems and bioreactors including a consideration of mass transport processes.
Prerequisites: AS.020.306 OR ( EN.580.440 or EN.580.441 )
Instructor(s): M. Betenbaugh
Area: Engineering.

 

EN.540.403. Colloids and Nanoparticles. 3 Credits.

Fundamental principles related to interactions, dynamics, and structure in colloidal, nanoparticle, and interfacial systems. Concepts covered include hdrodynamics, Brownian motion, diffusion, sedimentation, electrophoresis, colloidal and surface forces, polymeric forces, aggregation, deposition, and experimental methods. Modern topics related to colloids in nano- science and technology will be discussed throughout the course with frequent references to recent literature. Meets with EN.540.603
Instructor(s): M. Bevan
Area: Engineering.

 

EN.540.405. The Design of Biomolecular Systems. 3 Credits.

This course covers new topics in the design of systems of biomolecules,w both in vitro and in vivo, for decision making and control. The course will begin with an overview of how logical decision making and control with biomolecules as is achieved in biology and then proceed to consider various strategies of engineering similar systems. The focus of the course will be on systems level principles rather than the biochemistry of molecule design. Topics will include engineering of transcriptional networks and genetic control for logically programming of cells, the design of in vitro mimics of genetic controls, molecular computing and systems aspects of metabolic engineering. The course will also cover quantitative and computational techniques for the simulation and analysis of biomolecular systems. Recommended: EN.540.402; Upper level undergrads. Meets with EN.540.605
Instructor(s): R. Schulman.

 

EN.540.407. Current Topics in Functional Molecular Assembly. 3 Credits.

This course describes the most recent progress in molecular self-assembly, with a focus on the application aspects of self-assembling materials in medical and energy-related areas. Specifically, the course consists of about twelve lectures covering a broad range of topics, including: principles of static and dynamic molecular assembly, nanomaterials and phase/morphology diagrams of small molecular and macromolecular amphiphiles, self-assembly in biological systems, supramolecular polymers for energy and medicine, key challenges in the fabrication of organic solar cells, and self-healing materials. The class will be taught in a seminar format, with discussions led by graduate students or postdocs. Instructor permission required. Juniors and Seniors only.
Instructor(s): H. Cui.

 

EN.540.409. Modeling Dynamic/Control. 4 Credits.

Introduction to modeling, dynamics, and control. Unsteady state analysis of biomolecular and chemical process control systems. State space and Laplace transform techniques, block diagram algebra, and transfer functions. Feedback and feedforward control. Frequency response and stability analysis. Model construction for biomolecular and cellular systems including pharmacokinetic modeling, biomolecular modeling using the central dogma of biology/control of gene expression, large scale biosimulation. Introduction to nonlinear dynamics. Recommended Corequisites: AS.110.302, EN.540.203, EN.540.301, EN.540.303, AS.020.305 and AS.020.306 or equivalent.
Instructor(s): A. Goffin
Area: Engineering, Quantitative and Mathematical Sciences.

 

EN.540.414. Computational Protein Structure Prediction. 3 Credits.

This class will introduce the fundamental concepts in protein structure, biophysics, optimization and informatics that have enabled the breakthroughs in computational structure prediction and design. Problems covered will include protein folding and docking, design of ligand-binding sites, design of turns and folds, design of protein interfaces. Class will consist of lectures and hands-on computer workshops. Students will learn to use molecular visualization tools and write programs with the PyRosetta protein structure software suite, including a computational project. Programming experience is recommended.
Instructor(s): J. Gray
Area: Engineering.

 

EN.540.415. Interfacial Science with Applications to Nanoscale Systems. 3 Credits.

Nanostructured materials intrinsically possess large surface area (interface area) to volume ratios. It is this large interfacial area that gives rise to many of the amazing properties and technologies associated with nanotechnology. In this class we will examine how the properties of surfaces, interfaces, and nanoscale features differ from their macroscopic behavior. We will compare and contrast fluid-fluid interfaces with solid-fluid and solid-solid interfaces, discussing fundamental interfacial physics and chemistry, as well as touching on state-of-the-art technologies.
Instructor(s): J. Frechette.

 

EN.540.416. Current Topics in Protein Structure Prediction. 3 Credits.

This course will consist of student-led discussions of current literature in protein structure prediction, protein-protein docking, and computational protein design. Related advanced computational approaches of the Rosetta3 protein structural modeling platform will be discussed and object-oriented software design concepts dissected. Students will present and critique C++ and Python code and scripts corresponding to related research projects. Permission of Instructor Required
Instructor(s): J. Gray.

 

EN.540.418. Projects in the Design of a Chemical Car. 2 Credits.

Ready to put those concepts from class into practice? Members work over the course of the semester to design and build a chemically powered vehicle that will compete with other college teams at the American Institute of Chemical Engineers ( AIChE) Regional Conference. In this course, the students work in small groups to design and construct the chassis along with chemically powered propulsion and break mechanisms within the constraints of the competition. In addition, students will give oral presentation, write reports, and do thorough safety analysis of their prototypes. Both semesters must be completed with passing grades to receive credit.
Instructor(s): L. Dahuron
Area: Engineering.

 

EN.540.419. Projects in the Design of a Chemical Car. 2 Credits.

Ready to put those concepts from class into practice? Members work over the course ofthe semester to design and build a chemically powered vehicle that will compete with other college teams at the American Institute of Chemical Engineers ( AIChE) Regional Conference. In this course, the students work in small groups to design and construct the chassis along with chemically powered propulsion and break mechanisms within the constraints of the competition. In addition, students will give oral presentation, write reports, and do thorough safety analysis of their prototypes.
Prerequisites: EN.540.418
Instructor(s): J. Frechette; L. Dahuron.

 

EN.540.420. Build-a-Genome. 4 Credits.

In this combination lecture/laboratory “Synthetic Biology” course students will learn how to make DNA building blocks used in an international project to build the world’s first synthetic eukaryotic genome, Saccharomyces cerevisiae v. 2.0. Please study the wiki www.syntheticyeast.org for more details about the project. Following a biotechnology boot-camp, students will have 24/7 access to computational and wet-lab resources and will be expected to spend 15-20 hours per week on this course. Advanced students will be expected to contribute to the computational and biotech infrastructure. Co-listed with 020.420 and 580.420. Students must understand fundamentals of DNA structure, DNA electrophoresis and analysis, Polymerase Chain Reaction (PCR) and must be either a) Experienced with molecular biology lab work or b) Adept at programming with a biological twist.
Instructor(s): J. Boeke
Area: Engineering, Natural Sciences.

 

EN.540.421. Project in Design: Pharmacodynamics. 3 Credits.

This course covers pharmacodynamics, i.e. how pharmaceuticals affect biological processes. The course will use MatLab to aid in the design of new drug formulations.
Instructor(s): M. Donohue
Area: Engineering.

 

EN.540.426. Biomacromolecules at the Nanoscale. 3 Credits.

This course introduces modern concepts of polymer physics at the nanoscale to describe the conformation and dynamics of biological macromolecules such as filamentous actin, microtubule, and nucleic acids. We will introduce scattering techniques, nano-manipulation techniques, as well as nano-rheology applied to the study of polymers for tissue engineering, nanoparticles, and drug delivery applications.
Instructor(s): D. Wirtz
Area: Engineering.

 

EN.540.428. Supramolecular Materials and Nanomedicine. 3 Credits.

Nanomedicine is a quickly growing area that exploits the novel chemical, physical, and biological properties of nanostructures and nanostructured materials for medical treatments. This course presents basic design principles of constructing nanomaterials for use in drug delivery, disease diagnosis and imaging, and tissue engineering. Three major topics will be discussed, including 1) nanocarriers for drug delivery that are formed through soft matter assembly (e.g., surfactants, lipids, block copolymers, DNA, polyelectrolytes, peptides), 2) inorganic nanostructures for disease diagnosis and imaging (e.g., nanoparticles of gold and silver, quantum dots and carbon nanotubes), and 3) supramolecular scaffolds for tissue engineering and regenerative medicine. Students are expected to learn the physical, chemical and biological properties of each nanomaterial, the underlying physics and chemistry of fabricating such material, as well as their advantages and potential issues when used for biomedical applications. This course will also provide students opportunities for case studies on commercialized nanomedicine products. After this class, students should gain a deeper understanding of current challenges in translating nanoscience and nanotechnology.
Prerequisites: EN.540.204 AND AS.020.305 or instructor’s permission.
Instructor(s): H. Cui
Area: Engineering, Natural Sciences.

 

EN.540.437. Application of Molecular Evolution to Biotechnology. 3 Credits.

One of the most promising strategies for successfully designing complex biomolecular fuinctions is to exploit nature’s principles of evolution. This course provides an overview of the basics of molecular evolution as well as its experimental implementation. Current research problems in evolution-based biomolecular engineering will be used to illustrate principles in the design of biomolecules (i.e. protein engineering, RNA/DNA engineering), genetic circuits and complex biological systems including cells. Meets with EN.540.637
Prerequisites: AS.020.305 OR EN.580.221
Instructor(s): M. Ostermeier
Area: Engineering, Natural Sciences.

 

EN.540.440. Micro/Nanotechnology: The Science and Engineering of Small Structures. 3 Credits.

Micro/Nanotechnology is the field of fabrication, characterization and manipulation of extremely small objects (dimensions on the micron to nanometer length scale). Microscale objects, because of their small size are expected to be at the frontier of technological innovation for the next decade. This course will include a description of the materials used in microtechnology, methods employed to fabricate nanoscale objects, techniques involved in characterizing and exploiting the properties of small structures, and examples of how this technology is revolutionizing the areas of Electronics & Medicine. Same class as 540.640 Same course as 540.640
Instructor(s): D. Gracias
Area: Engineering.

 

EN.540.443. Topics in Vascular Engineering. 3 Credits.

In-depth discussion and hands-on course focused on engineering approaches for vascular regeneration. The course will focus on engineering principles of the vasculature including induction of differentiation and administration of cell therapies. Seminal papers and approaches to analyze vascular tissues and cultures will be examined and discussed. Students will perform hands on experiments focused on vascular differentiation and regeneration. In addition, the course will be integrated with students’ presentations throughout the semester on selected topics in vascular engineering.
Instructor(s): S. Gerecht
Area: Engineering.

 

EN.540.444. Current Topics in Stem Cell Engineering. 3 Credits.

A selection of problems in fluid mechanics at low and moderate Reynolds numbers. This is a highly interactive class in which students are expected to choose topics and prepare a presentation at least twice a semester. Therefore, the list of problems will vary depending on student selection. Typically, on Tuesdays will be an introductory class and Thursdays will be seminars on a specific topic or paper.
Area: Engineering, Natural Sciences.

 

EN.540.446. Survey of Synthetic Biology. 1 Credit.

Area: Engineering.

 

EN.540.447. Advanced Problems in Fluid Mechanics. 3 Credits.

A selection of problems in fluid mechanics at low and moderate Reynolds numbers. This is a highly interactive class in which students are expected to choose topics and prepare a presentation at least twice a semester. Therefore, the list of problems will vary depending on student selection. Typically Tuesdays will be an introductory class and Thursdays will be seminars on a specific topic or paper. Meets with 540.647
Instructor(s): G. Drazer
Area: Engineering, Natural Sciences.

 

EN.540.448. Current Topics in Colloid Science. 3 Credits.

Instructor(s): M. Bevan
Area: Engineering.

 

EN.540.449. Logic and Decision-making in Biomolecular Systems. 3 Credits.

From the smallest change in gene expression to life and death and reproduction, biomolecular decision-making processes govern cellular fate. In this course we explore the design principles by which biomolecules make decisions and orchestrate complex processes such as signal transduction, homeostasis or apoptosis. We will also explore how we can in turn design complex biomolecular networks that can control biological systems and biomolecular materials. Topics will include the design and analysis of molecular logic circuits, transcriptional and translational control, signal transduction cascades, biomolecular oscillators and cycles, DNA nanotechnology and nanobiotechnology, and molecular computing. The course will introduce principles from electrical circuit theory, computing and control theory and show how these tools can be applied to these systems. Students should be familiar with programming and chemical engineering principles.
Instructor(s): R. Schulman
Area: Engineering, Natural Sciences.

 

EN.540.450. Current Topics in Transport and Interfacial Phenomena. 3 Credits.

Instructor(s): G. Drazer; J. Frechette
Area: Engineering.

 

EN.540.459. Bioengineering in Regenerative Medicine. 3 Credits.

Introduction and in-depth discussion course focused on tissue and stem cell engineering. The course will focus on principles in tissue engineering, mechanisms of regeneration, and stem cell therapies. Topics will include introduction to regenerative medicine, bioreactors and scaffolds in tissue engineering, adult and pluripotent stem cells, engineering the niche, and two sessions will focus on legal and ethical issues. Selected approaches to analyze tissues and stem cell culture will also be discussed. In addition, the course will be integrated with graduate students’ presentations on selected topics in stem cell engineering. Meets with EN.540.659
Prerequisites: AS.020.306 OR EN.580.221
Instructor(s): S. Gerecht
Area: Engineering.

 

EN.540.460. Computational and Experimental Design of Biomolecules. 3 Credits.

This course reviews current research problems in biomolecular design both from computational and experimental approaches. Current methods in structure prediction (folding, docking and design) will illustrate fundamental concepts in protein structure, biophysics, and optimization. Current research problems in evolution-based biomolecular engineering will illustrate principles in the design of biomolecules (i.e. protein engineering, RNA/DNA engineering), metabolic pathways, signaling pathways, genetic circuits and complex biological systems including cells. Recommended Course Background: AS.020.305
Area: Engineering.

 

EN.540.463. Current Topics: Biochemistry and Biophysics of Cancer. 3 Credits.

*Attendance to this course is limited to ChemBE students who are working in the instructors lab. This course focuses on the application of engineering fundamentals to cancer metastasis. Class lectures will include an overview of molecular biology fundamentals, an extensive review on extracellular matrix and basics of receptors, followed by topics on tumor cell-host cell and tumor cell-matrix interactions at both theoretical and experimental levels. Lectures will also cover the effects of physical (e.g. shear stress, strain) and chemical (e.g. cytokines, growth factors) stimuli on tumor cell function.
Instructor(s): K. Konstantopoulos
Area: Engineering.

 

EN.540.464. Current Topics: The Statistical Mechanics of Malignant Neoplasm. 3 Credits.

This course will introduce students involved in cancer engineering research the fundamental elements of statistical mechanics relevant to tumor growth and progression to metastatic disease. Topics include: Fokker-Planck equation for collective cancer migration, tumor growth as a phase transition, and cancer cell motility in nth-dimension space.
Instructor(s): D. Wirtz.

 

EN.540.472. Topics in Vascular Engineering. 3 Credits.

In-depth discussion and hands-on course focused on engineering approaches for vascular regeneration. The course will focus on engineering principles of the vasculature including induction of differentiation and administration of cell therapies. Seminal papers and approaches to analyze vascular tissues and cultures will be examined and discussed. Students will perform hands on experiments focused on vascular differentiation and regeneration. In addition, the course will be integrated with students’ presentations throughout the semester on selected topics in vascular engineering.
Area: Engineering.

 

EN.540.475. Macromolecules at Interface. 3 Credits.

By instructor’s permission. This course involves integrated lecture/discussion and laboratory components to review and participate in current and emerging topics involving macromolecules at interfaces. Lectures and discussions review how fundamentals of macromolecular and interfacial science are connected to emerging problems in nano- and bio- technologies. Authentic inquiry activities in the laboratory are connected to diverse scientific and technological fundamental topics. Research and journal article presentations provide a context for laboratory activities with respect to current topics in a number of emerging research applications involving colloidal particles. Research design and strategy is discussed as a process distinct from existing elective course activities and guided inquiry activities in standard undergraduate laboratory courses. Applications include (but are not limited to) photonic crystals, reconfigurable antennas, drug delivery, biomolecular interactions, nanoparticles in the environment, and tissue engineering.
Instructor(s): M. Bevan
Area: Engineering.

 

EN.540.477. Current Topics in Transport and Interfacial Phenomena: Electrokinetics. 3 Credits.

This course involves integrated lecture/discussion and laboratory components to review and participate in current and emerging topics involving fluid mechanics and interfacial science. The lectures and discussions review how fundamentals of transport and interfacial science are connected to emerging problems in micro- and nanotechnologies. The focus area of the class is Electrokinetic Phenomena. The mandatory laboratory component is aimed at connecting the topics covered in the class to scientific problems. Student participation will involve presentation of laboratory results and research papers.
Instructor(s): G. Drazer; J. Frechette; Z. Gagnon.

 

EN.540.478. Current Aspects of Transport and Interfacial Phenomena Part 2. 3 Credits.

By instructor’s permission. This course involves integrated lecture/discussion and laboratory components to review and participate in current and emerging topics involving fluid mechanics and interfacial science. The lectures and discussions review how fundamentals of transport and interfacial science are connected to emerging problems in micro- and nanotechnologies. The mandatory laboratory component is aimed at connecting the topics covered in the class to scientific problems. Student participation will involve presentation of laboratory results and research papers.
Instructor(s): G. Drazer; J. Frechette
Area: Engineering.

 

EN.540.479. Current Topics in Eukaryotic Cell Biotechnology. 3 Credits.

This course involves integrated lecture/discussion and laboratory components to review and participate in current and emerging topics involving eukaryotic biotechnology. Lectures and discussions review how fundamentals of biochemical kinetics and biomolecular engineering are connected to emerging problems in mammalian, algal, and stem cell biotechnology. Laboratory activities are connected to diverse scientific and technological fundamental topics on these same themes. Journal article and research presentations provide a context for laboratory activities with respect to emerging industrial applications for eukaryotic cell types. Research design and strategy is discussed in terms of its ultimate implementation in laboratory, pilot plant, and eventually manufacturing facilities. Methodologies implemented include cell and metabolic engineering for improving yields and production rates of proteins, cells, and tissues. Example topics include expansion of mammalian, stem cells, and algae for the production of membrane proteins, biologics, biofuels, and complex metabolites.
Instructor(s): M. Betenbaugh
Area: Engineering.

 

EN.540.480. Current Topics in Eukaryotic Cell Biotechnology Part II. 3 Credits.

This course involves integrated lecture/discussion and laboratory components to review and participate in current and emerging topics involving eukaryotic biotechnology. Lectures and discussions review how fundamentals of biochemical kinetics and biomolecular engineering are connected to emerging problems in mammalian, algal, and stem cell biotechnology. Laboratory activities are connected to diverse scientific and technological fundamental topics on these same themes. Journal article and research presentations provide a context for laboratory activities with respect to emerging industrial applications for eukaryotic cell types. Research design and strategy is discussed in terms of its ultimate implementation in laboratory, pilot plant, and eventually manufacturing facilities. Methodologies implemented include genomics, metabolic flux analysis, and cell and metabolic engineering for improving yields and production rates of proteins, cells, and tissues. Example topics include expansion of mammalian cells and algae for the production of membrane proteins, biologics, biofuels, and complex metabolites.
Instructor(s): M. Betenbaugh.

 

EN.540.490. Chemical Laboratory Safety. 1 Credit.

This course is meant to provide the student with a basic knowledge of laboratory safety; hazards, regulations, personal protective equipment, good laboratory practice, elementary toxicology, and engineering controls. It has been developed by the Department of Chemical and Biomolecular Engineering to assist with regulatory compliance, minimize hazards, and reduce the severity of any incidents that may occur in the department’s laboratories. The course is a prerequisite of EN.540.311/EN.540.313. It is required of all Chemical and Biomolecular Engineering undergraduates. In addition once per year a three-hour refresher seminar must be taken by all students involved in laboratory research.
Instructor(s): D. Kuespert; L. Dahuron.

 

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