This effort is focused on quantitative analysis and design of custom proteins, nucleic acids, and biomolecular complexes. Participating faculty members are creators of new tools and approaches for engineering biomolecules and apply these new technologies to solve some of the most pressing problems in biotechnology, pharmaceuticals, medicine and bioengineering. These approaches range from rational and computational methods to evolutionary design approaches, and the products span customized enzymes, molecular switches, therapeutic antibodies, ion channels, membranes, and DNA assemblies. Several studies use the designed biomolecular components to drive processes at larger length sales and time scales, such as cellular decision- making, synthetic biology, and materials formation (see area 3).
Jeffrey Gray is using computational structure prediction and design methods for antibody structure prediction, protein- protein docking, and design of protein-surface interactions.
Marc Ostermeier applies directed evolution and synthetic biology approaches to engineer proteins for biomedical and biotechnological applications.
Rebecca Schulman’s work uses techniques from molecular programming to rationally design complex, environmentally-adaptive DNA nanostructures.
Michael Betenbaugh’s work is directed at developing protein evolutionary technologies for implementation into mammalian cell lines.